Pakistani former Prime Minister Benazir Bhutto has been assassinated in a suicide attack.
Ms Bhutto - the first woman PM in an Islamic state - was leaving an election rally in Rawalpindi when a gunman shot her in the neck and set off a bomb.
At least 20 other people died in the attack and several more were injured.
President Pervez Musharraf has urged people to remain calm but angry protests have gripped some cities, with at least 11 deaths reported.
Security forces have been placed on a state of "red alert" nationwide.
There were no immediate claims of responsibility for the attack. Analysts believe Islamist militants to be the most likely group behind it.
Ms Bhutto, leader of the Pakistan People's Party (PPP), had served as prime minister from 1988-1990 and 1993-1996, and had been campaigning ahead of elections due on 8 January.
It was the second suicide attack against her in recent months and came amid a wave of bombings targeting security and government officials.Nawaz Sharif, also a former prime minister and a political rival, announced his Muslim League party would boycott the elections.
He called on President Musharraf to resign, saying free and fair elections were not possible under his rule.
The United Nations Security Council held an emergency session and later said it "unanimously condemned" the assassination.
Scene of grief
Ms Bhutto's coffin was removed from hospital in Rawalpindi and has now arrived by plane in Sukkur in Sindh province for burial in her home town, Larkana.
Her husband, Asif Ali Zardari, has arrived in Pakistan from Dubai to escort the coffin to its final resting-place.
The attack occurred close to an entrance gate of the city park where Ms Bhutto had been speaking.
Police confirmed reports Ms Bhutto had been shot in the neck and chest before the gunman blew himself up.
She died at 1816 (1316 GMT), said Wasif Ali Khan, a member of the PPP who was at hospital.
Some supporters at the hospital wept while others broke into anger, throwing stones at cars and breaking windows.
Protests erupted in other cities as news of the assassination spread, with reports of 11 deaths in the PPP's heartland province of Sindh, including four in provincial capital, Karachi.
More than 100 cars were burned in Karachi, while cars and a train were reportedly set on fire in Hyderabad.
In other violence:
'Security lapse'
Mr Musharraf has announced three days of national mourning. All schools, colleges, universities, banks and government offices will remain closed.
Mr Sharif said there had been a "serious lapse in security" by the government.
Earlier on Thursday, at least four people were killed ahead of an election rally Mr Sharif had been preparing to attend close to Rawalpindi.
Ms Bhutto's death has plunged the PPP into confusion and raises questions about whether January elections will go ahead as planned, the BBC's Barbara Plett in Islamabad says.
The killing was condemned by India, the US, the UK and others.
US President George W Bush telephoned Mr Musharraf for what the White House would only describe as a "brief" conversation on the situation.
Ms Bhutto returned from self-imposed exile in October after years out of Pakistan where she had faced corruption charges.
Her return was the result of a power-sharing agreement with President Musharraf
He had granted an amnesty that covered the court cases she was facing.
But relations with Mr Musharraf soon broke down.
On the day of her arrival, she had led a motor cavalcade through the city of Karachi.
It was hit by a double suicide attack that left some 130 dead.
Rawalpindi, the nerve centre of Pakistan's military, is seen as one of the country's most secure cities.
Many analysts say attacks like those on Thursday show the creeping "Talebanisation" of Pakistan.
Radical Muslims calling for Islamic law, and fiercely opposed to the US, have become increasingly active in Pakistani politics in recent years, analysts say.
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From CNN.com
The photographer who took images of former Pakistani Prime Minister Benazir Bhutto moments before her assassination Thursday told CNN he was "surprised" to see her rise through the sunroof of her vehicle to wave to supporters after delivering her speech.
"I ran up, got as close as I got, made a few pictures of her waving to the crowd," Getty Images senior staff photographer John Moore told CNN's online streaming news service, CNN.com Live, in a phone interview Thursday from Islamabad, Pakistan.
"And then suddenly, there were a few gunshots that rang out, and she went down, she went down through thesunroof," he said. "And just at that moment I raised my camera up and the blast happened. ... And then, of
course, there was chaos." Watch Moore describe Bhutto's final moments HERE.
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